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However, treatments with GABA, DSIP-CBBBP, and DSIP all resulted in increased struggle times compared to the model group, with CBBBP alone not showing a similar effect, indicating a differential impact on depressive-like behaviors and highlighting the potential therapeutic value of these treatments in addressing depressive symptoms associated with insomnia (Vargas and Perlis, 2020)

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And the discontinuation rate due to adverse events runs roughly 2-3 times higher than tirzepatide at equivalent trial timepoints

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